Sana D Karam Selected Research

Squamous Cell Carcinoma of Head and Neck

3/2024	IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models.
3/2024	Durvalumab in combination with chemoradiotherapy in patients with head and neck squamous cell carcinoma: Results from the Phase 1 CLOVER study.
2/2024	Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs.
1/2024	Publisher Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC.
1/2023	Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC.
1/2023	Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC.
11/2022	A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC.
5/2022	Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma.
1/2022	The role of concomitant chemoradiotherapy versus radiation alone in T1-3N0 HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma.
1/2022	EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.

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Sana D Karam Research Topics

Disease

79	Neoplasms (Cancer) 03/2024 - 01/2012
30	Squamous Cell Carcinoma of Head and Neck 03/2024 - 01/2014
19	Head and Neck Neoplasms (Head and Neck Cancer) 03/2024 - 01/2014
8	Neoplasm Metastasis (Metastasis) 03/2024 - 01/2014
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 01/2013
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023 - 01/2021
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2023 - 01/2017
4	Laryngeal Neoplasms (Laryngeal Cancer) 12/2022 - 01/2017
4	Medulloblastoma 01/2017 - 04/2015
3	Adenocarcinoma 01/2023 - 04/2021
3	Inflammation (Inflammations) 01/2023 - 01/2017
3	Oropharyngeal Neoplasms 01/2019 - 11/2018
3	Carcinoma (Carcinomatosis) 11/2018 - 06/2012
2	Edema (Dropsy) 10/2023 - 02/2023
2	Breast Neoplasms (Breast Cancer) 10/2023 - 02/2023
2	Glioma (Gliomas) 01/2023 - 01/2023
2	Fibrosis (Cirrhosis) 01/2021 - 01/2019
2	Brain Neoplasms (Brain Tumor) 10/2018 - 12/2017
2	Melanoma (Melanoma, Malignant) 10/2018 - 12/2017
1	Leukopenia 03/2024
1	Neutropenia 03/2024
1	Anemia 03/2024
1	Disease Progression 03/2024
1	Hypersensitivity (Allergy) 01/2024
1	Brain Edema (Cerebral Edema) 02/2023
1	Vasculitis (Vasculitides) 01/2023
1	Mouth Neoplasms (Oral Cancer) 01/2022
1	Stomatitis 01/2022
1	Epstein-Barr Virus Infections 12/2021
1	Neoplasm Micrometastasis 11/2021

Drug/Important Bio-Agent (IBA)

7	Immune Checkpoint InhibitorsIBA 03/2024 - 01/2017
7	Proteins (Proteins, Gene)FDA Link 01/2023 - 04/2015
6	durvalumabIBA 03/2024 - 11/2022
5	Cetuximab (Erbitux)FDA Link 01/2021 - 09/2017
4	Cisplatin (Platino)FDA LinkGeneric 03/2024 - 09/2017
4	LigandsIBA 01/2024 - 04/2015
4	Biomarkers (Surrogate Marker)IBA 11/2022 - 01/2020
4	Messenger RNA (mRNA)IBA 01/2018 - 04/2015
3	InterferonsIBA 01/2024 - 01/2021
3	CytokinesIBA 01/2023 - 11/2021
3	EphB4 ReceptorIBA 01/2022 - 12/2016
3	Phosphotransferases (Kinase)IBA 12/2016 - 04/2015
3	tyrosine receptor (receptor, tyrosine)IBA 12/2016 - 04/2015
2	RNA (Ribonucleic Acid)IBA 03/2024 - 02/2024
2	Topiramate (Topamax)FDA LinkGeneric 10/2023 - 02/2023
2	Antisense OligonucleotidesIBA 03/2022 - 04/2021
2	Neoplasm Antigens (Tumor Antigens)IBA 01/2022 - 12/2019
2	ChemokinesIBA 04/2021 - 01/2020
2	olaparibIBA 01/2020 - 10/2018
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2020 - 09/2015
2	Ephrin-B2 (Ephrin B2)IBA 01/2018 - 01/2017
2	EphrinsIBA 09/2015 - 04/2015
1	Interleukin-7 (Interleukin 7)IBA 03/2024
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 03/2024
1	Alanine Transaminase (SGPT)IBA 03/2024
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2024
1	Bevacizumab (Avastin)FDA Link 02/2023
1	SteroidsIBA 02/2023
1	RNA Polymerase II (RNA Polymerase B)IBA 01/2023
1	ChromatinIBA 01/2023
1	Interleukin-2 (IL2)IBA 01/2023
1	IntegrinsIBA 01/2023
1	AntigensIBA 01/2023
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2023
1	Laminin (Merosin)IBA 01/2023
1	Dinoprostone (PGE2)FDA Link 01/2023
1	Therapeutic UsesIBA 01/2022
1	tat Gene Products (tat Protein)IBA 01/2022
1	CarcinogensIBA 01/2022
1	HLA-A Antigens (HLA-A)IBA 01/2022
1	Ephrin-B1 (Ephrin B1)IBA 11/2021
1	flt3 ligand protein (flt3 ligand)IBA 11/2021
1	Angiotensin Receptor AntagonistsIBA 11/2021
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2021
1	Gefitinib (Iressa)FDA Link 01/2021
1	DisintegrinsIBA 01/2021
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2021
1	Complement System Proteins (Complement)IBA 01/2021
1	Anaphylatoxin C5a ReceptorIBA 01/2021
1	Metalloproteases (Metalloproteinases)IBA 01/2021
1	ErbB Receptors (EGF Receptor)IBA 01/2021
1	B7-H1 AntigenIBA 01/2021
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2021

Therapy/Procedure

48	Radiotherapy 03/2024 - 01/2012
27	Therapeutics 01/2023 - 01/2014
17	Immunotherapy 03/2024 - 01/2017
9	Drug Therapy (Chemotherapy) 01/2023 - 01/2014
6	Chemoradiotherapy 03/2024 - 01/2016
4	Neoadjuvant Therapy 01/2023 - 08/2017
4	Aftercare (After-Treatment) 01/2019 - 01/2014
3	Re-Irradiation 01/2021 - 06/2012
2	Laryngectomy 12/2022 - 02/2017
2	Radioimmunotherapy 11/2021 - 01/2019
2	Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated) 10/2018 - 01/2014
2	Induction Chemotherapy 02/2017 - 01/2017
2	Combined Modality Therapy 01/2016 - 01/2014
1	Craniospinal Irradiation 01/2023
1	Psychotherapy Imagery (Guided Imagery) 09/2022
1	Relaxation Therapy (Relaxation Technique) 09/2022
1	Pancreatectomy 01/2022